In recent days, after I wrote about PNIRS, I received the same question from founders, researchers, and investors, phrased in different ways: and the money, where is the money? I heard this from people I've known for years, people who built good science within universities, started companies, won grants, and then saw their projects stall not due to technical failures, but due to a lack of a next step . It is about this next step that I want to write, because it contains the m

Last week, Insilico Medicine announced the start of Phase III trials for rentosertib, an oral TNIK inhibitor for idiopathic pulmonary fibrosis (IPF). At first glance, the news seems like just another biotechnology milestone among many. But it's unlike anything we've seen so far, and it's worth understanding why before we return to the discussion about the Brazilian program for radical innovation in healthcare. Rentosertib is the first molecule in history to reach a pivotal Ph

Two doses per year could reshape HIV prevention, but price and licensing issues may limit scalability within the Brazilian public health system (SUS). The “quasi-vaccine” developed by Gilead Sciences arrives in Brazil with rare clinical evidence and global regulatory endorsement. But the geopolitics of voluntary licenses and the pricing logic in rich markets create a dilemma: how to remunerate innovation without turning prevention into a luxury incompatible with universality

How the global shift in health innovation redefines the role of industrial policies and exposes the backwardness of Brazil's strategy The pharmaceutical industry is experiencing a historic shift. The model that, for half a century, concentrated drug discovery in large, integrated corporations is fragmenting. Vertical integration, a symbol of strength in the 20th century, has given way to a decentralized network of small biotechs , academic laboratories, and deep tech startup

The modernization of Brazil’s foreign exchange framework, introduced by Law No. 14,286/2021 , has been presented as a regulatory advancement. However, behind the discourse of simplification and international alignment lies a serious risk: the deepening of Brazil’s technological dependence on core economies. Rather than strengthening national economic sovereignty, the new law further opens the door to the outflow of foreign currency and the unrestricted transfer of knowledge a